Produced from the bark of Drymis winteri. Naturally occurring drimane sesquiterpene found in water pepper (Polygonum hydropiper) which has been used in folk medicine for a variety of indications. Potent and selective activator of TRPA1 (EC50= 400nM).
Product Details
| Alternative Name: | (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde |
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| Formula: | C15H22O2 |
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| MW: | 234.3 |
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| Source: | Isolated from Polygonum hydropiper. |
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| CAS: | 6754-20-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off white solid or waxy solid. |
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| Solubility: | Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Metamorphosis of the invasive ascidian Ciona savignyi: environmental variables and chemical exposure: P.L. Cahill, et al.; PeerJ.
4, e1739 (2016),
Application(s): Cell culture,
Abstract;
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Antifungal activity of drimane sesquiterpenes from Drimys brasiliensis using bioassay-guided fractionation: A. Malheiros, et al.; J. Pharm. Pharm. Sci.
8, 335 (2008),
Abstract;
TRPA1 mediates the noxious effects of natural sesquiterpene deterrents: J. Escalera, et al.; J. Biol. Chem.
283, 24136 (2008),
Abstract;
Inhibition of the mitochondrial ATP synthesis by polygodial, a naturally occurring dialdehyde unsaturated sesquiterpene: M. V. Castelli, et al.; Biochem. Pharmacol.
70, 82 (2005),
Abstract;
Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats: E. Andre, et al.; Neuropharmacology.
46, 590 (2004),
Abstract;
