| ALX-801-051-L001 | 1 ml | 1,142.00 USD |  |
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| Alternative Name: | BRST-2 |
| Clone: | D6 |
| Host: | Mouse |
| Isotype: | IgG2a |
| Immunogen: | GCDFP-15 (gross cystic disease fluid protein-15; BRST-2). |
| UniProt ID: | P12273 |
| Species reactivity: | Human |
| Applications: | IHC (PS) |
| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections): Formalin-fixed, paraffin-embedded tissues; pre-treatment not required; suggested dilution: ≥1:40 for biotin based detection. For optimal staining, incubate primary antibody 20-60 minutes at room temperature). Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | This antibody is heat sensitive. Paraffin sections that have been heat fixed at 60°C may lose antibody binding site. |
| Positive Control: | Human axilla or breast carcinoma. |
| Formulation: | Liquid. In 0.01M PBS containing 1% BSA and 0.1% sodium azide . |
| Shipping: | Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | Gross cystic disease is a common premenopausal disorder in which gross cysts are the predominant pathologic lesion. It is characterized by production of a fluid secretion which accumulates in the breast cysts. Gross cystic disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15kDa monomer protein, GCDFP-15. The cells within the body that produce GCDFP-15 appear to be restricted primarily to those with apocrine function. Studies have found GCDFP-15 to be a highly specific and sensitive marker for breast cancer. GCDFP-15 is expressed by apocrine sweat glands, eccrine glands (variable), minor salivary glands, bronchial glands, metaplasmic epithelium of the breast, benign sweat gland tumors of the skin and the serous cells of the submandibular gland. Breast carcinomas (primary and metastatic lesions) with apocrine features express GCDFP-15. GCDFP-15 is positive in extramammary Paget's Disease. Other tumors tested are negative. |
| Regulatory Status: | RUO - Research Use Only |
