Product Details
| Alternative Name: | Major vault protein/Lung resistance protein |
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| Clone: | LRP-56 |
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| Host: | Mouse |
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| Isotype: | IgG2b |
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| Immunogen: | Human MVP/LRP (major vault protein/lung resistance protein). |
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| UniProt ID: | Q14764 |
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| Species reactivity: | Human
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| Specificity: | Recognizes an internal epitope (P110) of human MVP/LRP, which is overexpressed in various human non-P-glycoprotein MDR tumor cell lines. |
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| Applications: | Flow Cytometry, ICC, IHC (FS), IHC (PS)
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| Recommended Dilutions/Conditions: | Recommended starting dilution is 1:20. Suggested dilutions/conditions may not be available for all applications. Optimal should be determined individually for each application. |
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| Application Notes: | Flow Cytometry: cell permeabilization required)
Immunocytochemistry: cytospin preparations |
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| Positive Control: | Cell lines: Appropriate drug-sensitive parental cell lines and their multdrug resistant derivatives prepared by the same methods as the test specimens should be used as control materials.
Tissue: Human colon, kidney, bronchus or adrenal are recommended. |
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| Formulation: | Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Liver cells stained with LRP-56 (ALX-801-005).
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Product Literature References
The formation of vault-tubes: a dynamic interaction between vaults and vault PARP: A. Van Zon, et al.; J. Cell Sci.
116, 4391 (2003),
Abstract;
Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies: A.B. Schroeijers, et al.; J. Histochem. Cytochem.
49, 1379 (2001),
Abstract;
Immunohistochemical analysis of drug resistance-associated proteins in ovarian carcinomas: D. Mayr, et al.; Pathol. Res. Pract.
196, 469 (2000),
Abstract;
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines: A.B. Schroeijers, et al.; Cancer Res.
60, 1104 (2000),
Abstract;
Full Text
Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues: A.B. Schroeijers, et al.; Am. J. Pathol.
152, 373 (1998),
Abstract;
Identification of novel drug resistance-associated proteins by a panel of rat monoclonal antibodies: M.J. Flens, et al.; Int. J. Cancer
73, 249 (1997),
Abstract;
Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am. J. Pathol.
147, 1545 (1995),
Abstract;
Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance: R.J. Scheper, et al.; Cancer Res.
53, 1475 (1993),
Abstract;
