Potent and selective mouse/rat kynurenine aminotransferase II (KAT II) inhibitor. IC50=6.1µM.
Product Details
| Alternative Name: | (S)-(4-Ethylsulfonyl)benzoylalanine . hydrochloride |
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| Formula: | C12H15NO5S . HCl |
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| MW: | 285.3 . 36.5 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum: L. Amori, et al.; Neuroscience
159, 196 (2009),
Abstract;
Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis: F. Rossi, et al.; Curr. Opin. Struct. Biol.
18, 748 (2008),
Abstract;
Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA: R. Pellicciari, et al.; ChemMedChem
3, 1199 (2008),
Abstract;
Toxoplasma gondii and schizophrenia: linkage through astrocyte-derived kynurenic acid?: R. Schwarcz & C.A. Hunter; Shizophr. Bull.
33, 652 (2007),
Abstract;
Full Text
Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor: R. Pellicciari, et al.; ChemMedChem
1, 528 (2006),
Abstract;
