Type II positive allosteric modulator (PAM) of α7 neuronal nicotinic acetylcholine receptor (nAChR) (EC50=216nM). Shows no detectable effect on α4β2, α3β4 and α9α10 receptors.
Product Details
| Alternative Name: | NSC 216666, N-(5-Chloro-2,4-dimethoxyphenyl)-N’-(5-methyl-3-isoxazolyl)urea |
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| Formula: | C13H14ClN3O4 |
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| MW: | 311.7 |
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| CAS: | 501925-31-1 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by MS and NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (50mg/ml); slightly soluble in methanol (1mg/ml) or acetonitrile (0.5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Allosteric Modulators of the alpha7 Nicotinic Acetylcholine Receptor: R. Faghih, et al.; J. Med. Chem.
51, 701 (2008),
Abstract;
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes: J.H. Gronlien, et al.; Mol. Pharmacol.
72, 715 (2007),
Abstract;
A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization: R.S. Hurst, et al.; J. Neurosci.
25, 4396 (2005),
Abstract;
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