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Valproic acid . sodium salt

Anticonvulsant and anti-depressant



ALX-550-304-G005	5 g	46.00 USD
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Anticonvulsant, anti-depressant and potent teratogen. Inhibits histone deacetylase 1 (HDAC1) (IC₅₀=0.4mM). Inhibitor of human cytochrome P450 2C9 isoform (K_i=600µM). Inducer of apoptosis in human leukemia cells. In nude mice experiments, inhibits significantly human uterine tumor growth without toxic side effects. Modulates the firing of neurons.

Product Details

Alternative Name:	2-Propylpentanoic acid . Na, Sodium 2-propylpentanoate

Formula:	C₈H₁₅O₂ . Na

MW:	143.2 . 23.0

CAS:	1069-66-5

MI:	14: 9913

Purity:	≥98% (GC)

Appearance:	White to off-white powder.

Solubility:	Soluble in water (50mg/ml) or 100% ethanol.

Shipping:	Ambient Temperature

Long Term Storage:	+4°C

Handling:	Hygroscopic.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells: K. Kallsen, et al.; PLoS One 7, e50000 (2012), Abstract; Full Text

Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells: K. Huber, et al.; J. Biol. Chem. 286, 22211 (2011), Abstract; Full Text

Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1: S. Shetty, et al.; Mol. Cell. Biol. 25, 5404 (2005), Abstract; Full Text

Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells: N. Takai, et al.; Clin. Cancer Res. 10, 1141 (2004), Abstract;

Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathways: R. Kawagoe, et al.; Leuk. Res. 26, 495 (2002), Abstract;

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen: C.J. Phiel, et al.; J. Biol. Chem. 276, 36734 (2001), Abstract; Full Text

In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9): X. Wen, et al.; Br. J. Clin. Pharmacol. 52, 547 (2001), Abstract;

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells: M. Gottlicher, et al.; EMBO J. 20, 6969 (2001), Abstract;

Mechanisms of action of valproate: a commentatory: C.U. Johannessen; Neurochem. Int. 37, 103 (2000), (Review), Abstract;

Actions of sodium valproate on the central nervous system: G. Tunnicliff; J. Physiol. Pharmacol. 50, 347 (1999), (Review), Abstract;

Maternal valproic acid and congenital neural tube defects: E. Robert & P. Guibaud; Lancet 2, 937 (1982), Abstract;

The mechanism of action of sodium valproate: R.W. Kerwin & P.V. Taberner; Gen. Pharmacol. 12, 71 (1981), (Review), Abstract;

Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy: R.M. Pinder, et al.; Drugs 13, 81 (1977), (Review), Abstract;