Effective substrate and efficient inactivator of DNA alkyltransferase.
Product Details
| Formula: | C12H11N5O |
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| MW: | 241.2 |
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| CAS: | 19916-73-5 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Identity determined by 1H-NMR. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in methanol (20mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo: E.L. Kreklau, et al.; Pharmacol. Exp. Ther.
291, 1269 (1999),
Abstract;
O6-benzylguanine and its role in chemotherapy: M.E. Dolan & A.E. Pegg; Cancer Res.
3, 837 (1997),
Abstract;
Activation of human O6-alkylguanine-DNA alkyltransferase by DNA: K. Goodtzova, et al.; Biochemistry
33, 8385 (1994),
Abstract;
Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine: R.H. Elder, et al.; Biochem. J.
298, 231 (1994),
Abstract;
