Replaces Prod. #: BML-CN230
Protoporphyrin IX free acid, as distinct from its zinc salt (which inhibits heme oxygenase), activates soluble guanylyl cyclase (sGC) by binding directly to the enzyme. A useful reagent in cases where the use of nitric oxide (NO) or nitric oxide donors is undesirable.
Product Details
| Alternative Name: | 8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid |
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| Formula: | C34H34N4O4 |
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| MW: | 562.7 |
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| CAS: | 553-12-8 |
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| MI: | 14: 7897 |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by NMR and UV/VIS. |
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| Appearance: | Purple to dark brown solid. |
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| Solubility: | Dissolve initially in 0.1M base (Tris base or NaOH), then add water miscible organic solvent (EtOH (10mg/ml), MeOH, DMSO (10mg/ml), DMF) until solution is 50/50 base/solvent. When a clear solution is obtained, it can be diluted into an aqueous medium and titrated or buffered to any pH>7. Use immediately. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Make solutions fresh daily. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements: A. Walke, et al.; Sci. Rep.
13, 3829 (2023),
Abstract;
Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes: A. Nithichanon, et al.; Sci. Rep.
10, 10297 (2020),
Abstract;
Full Text
Photodynamic intramolecular crosslinking of myoglobin: J. van Steveninck & T.M.A.R. Dubbelman; Biochim. Biophys. Acta 791, 98 (1984),
Porphyrins and chlorophylls as probes for fluoroimmunoassays [letter]: J.L. Hendrix; Clin. Chem.
29, 1003 (1983),
Abstract;
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme: M.S. Wolin, et al.; J. Biol. Chem.
257, 13312 (1982),
Abstract;
Full Text
Model studies on photodynamic cross-linking: H. Verweij & J. Van Steveninck; Photochem. Photobiol.
35, 265 (1982),
Abstract;
