A potent mycotoxin and anti-mitotic compound. Causes lupinosis in livestock fed infected lupins. Binds selectively to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Binds to tubulin at a site overlapping that of vinblastine (Prod. No. ALX-350-257) and maytansine. Protects tubulin from decay.
Product Details
| Formula: | C36H45ClN6O12 |
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| MW: | 789.2 |
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| Source: | Isolated from Phomopsis leptostromiformis MST-FP2068. |
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| CAS: | 64925-80-0 |
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| RTECS: | SY2593000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in 100% ethanol, methanol, dimethylformamide or DMSO; slightly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Interaction of phomopsin A with normal and subtilisin-treated bovine brain tubulin: A.R. Chaudhuri & R.F. Luduena; J. Protein Chem.
16, 99 (1997),
Abstract;
The interaction of phomopsin A with bovine brain tubulin: R.F. Luduena, et al.; Arch. Biochem. Biophys.
272, 32 (1989),
Abstract;
Interaction of phomopsin A and related compounds with purified sheep brain tubulin: E. Lacey, et al.; Biochem. Pharmacol.
36, 2133 (1987),
Abstract;
General Literature References
Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B: E. Hamel; Pharmacol. Ther.
55, 31 (1992),
Abstract;
