Diterpene with potent anti-tumor activity. Induces apoptosis and autophagy.
Product Details
| Alternative Name: | Isodonol |
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| Formula: | C20H28O6 |
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| MW: | 364.4 |
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| Source: | Isolated from Rabdosia rubescens |
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| CAS: | 28957-04-2 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO (20mg/ml) or PEG 400; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells: Y. Cheng et al.; Autophagy
5, 430 (2009),
Abstract;
Apoptotic effect of oridonin on NB4 cells and its mechanism: J. Liu, et al.; Leuk. Lymphoma
46, 593 (2005),
Abstract;
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways: T. Ikezoe, et al.; Mol. Cancer Ther.
4, 578 (2005),
Abstract;
Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells: T. Ikezoe, et al.; Int. J. Oncol.
23, 1187 (2003),
Abstract;
