Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2).
Product Details
| Alternative Name: | (+)-Pyripyropene A, PPPA |
| |
| Formula: | C31H37NO10 |
| |
| MW: | 583.6 |
| |
| Source: | Isolated from Aspergillus fumigatus FO-1289. |
| |
| CAS: | 147444-03-9 |
| |
| Purity: | ≥85% (HPLC) |
| |
| Appearance: | White to brown powder. |
| |
| Solubility: | Soluble in DMSO,chloroform, methanol or ethyl acetate; insoluble in water or hexane. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
| Manufacturer: | Fungal strain courtesy of The Kitasato Institute, Tokyo. |
| |
Please mouse over
Product Literature References
Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther.
115, 375 (2007),
Abstract;
Exploiting PdII and TiIII chemistry to obtain gamma-dioxygenated terpenoids: synthesis of rostratone and novel approaches to aphidicolin and pyripyropene A: J. Justicia, et al.; J. Org. Chem.
70, 8265 (2005),
Abstract;
Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites: T. Sunazuka and S. Omura; Chem. Rev.
105, 4559 (2005),
Abstract;
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver: P. Parini, et al.; Circulation
110, 2017 (2004),
Abstract;
Full Text
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness: A.T. Lada, et al.; J. Lipid Res.
45, 378 (2004),
Abstract;
Full Text
Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation: K.H. Cho, et al.; BBRC
309, 864 (2003),
Abstract;
A formal synthesis of (+)-pyripyropene A using a biomimetic epoxy-olefin cyclisation: effect of epoxy alcohol/ether on cyclisation efficiency: V.K. Aggarwal, et al.; J. Chem. Soc. 3315 (1999),
Full Text
Meroterpenoids with various biological activities produced by fungi: K. Shiomi, et al.; Pure Appl. Chem.
71, 1059 (1999),
Full Text
Biosynthesis of Pyripyropene A: H. Tomoda, et al.; J. Org. Chem. 61, 882 (1996),
Aflavinines and other antiinsectan metabolites from the ascostromata of Eupenicillium crustaceum and related species: H.J. Wang, et al.; Appl. Environ. Microbiol.
61, 4429 (1995),
Abstract;
Full Text
Total Synthesis of (+)-Pyripyropene A, a Potent, Orally Bioavailable Inhibitor of Acyl-CoA:Cholesterol Acyltransferase: T. Nagamitsu, et al.; J. Org. Chem. 60, 8126 (1995),
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties: H. Tomoda, et al.; J. Antibiot.
47, 148 (1994),
Abstract;
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D: Y.K. Kim, et al.; J. Antibiot.
47, 154 (1994),
Abstract;
Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus: S. Omura, et al.; J. Antibiot.
46, 1168 (1993),
Abstract;
