Cyclic tetrapeptide. Inhibitor of chloroplast F1-ATPase (CF1). Does not inhibit the homologous enzymes from chloroplasts of insusceptible plant species or from bacteria or mitochondria.
Product Details
| Alternative Name: | cyclo-(N-Methyl-L-alanyl-L-leucyl-N-methyl-(Z)-dihydrophenylalanyl-glycyl) |
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| Formula: | C22H30N4O4 |
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| MW: | 414.5 |
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| Source: | Isolated from Alternaria alternata. |
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| CAS: | 28540-82-1 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Purity Detail: | Free of any peptide contaminations, especially dihydrotentoxin. |
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| Appearance: | Off-white to yellow powder. |
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| Solubility: | Soluble in DMSO (10mg/ml) or methanol (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase: Arch. Toxicol.; J. Kim, et al.
91, 2007 (2017),
Application(s): Impact on the activity of human and bacterial topo II.,
Abstract;
Complete inhibition and partial Re-activation of single F1-ATPase molecules by tentoxin: new properties of the re-activated enzyme: P. Pavlova, et al.; J. Biol. Chem.
279, 9685 (2004),
Abstract;
Full Text
Metabolism of tentoxin by hepatic cytochrome P-450 3A isozymes: M. Delaforge, et al.; Eur. J. Biochem.
250, 150 (1997),
Abstract;
Effects of tentoxin and dihydrotentoxin on human erythrocytes: K. Gwozdzinski, et al.; Cytobios.
67, 183 (1991),
Abstract;
