Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitocondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.
Product Details
| Formula: | C11H6F3NO2S |
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| MW: | 273.2 |
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| CAS: | 327033-36-3 |
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| Purity: | ≥95% (HPLC, TLC, NMR/ELSD) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (at least 5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma: Y.W. Lin, et al.; Blood
115, 824 (2010),
Abstract;
Regulation of Skp2 levels by the Pim-1 protein kinase: B. Cen, et al.; J. Biol. Chem.
285, 29128 (2010),
Abstract;
Full Text
Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells: Z. Beharry, et al.; Mol. Cancer Ther.
8, 1473 (2009),
Abstract;
Full Text
PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells: F. Zhang, et al.; Cancer Biol. Ther.
8, 846 (2009),
Abstract;
Full Text
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases: Z. Xia, et al.; J. Med. Chem.
52, 74 (2009),
Abstract;
