Potent, cell permeable and ATP-competitive inhibitor of DNA-PK, phosphoinositide 3-kinase (PI(3)K), the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. Exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10µM. Effectively blocks cell proliferation in glioma cell lines both in vitro and in vivo.
Product Details
| Alternative Name: | 3-(4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl)phenol |
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| Formula: | C19H16N4O3 |
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| MW: | 348.4 |
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| CAS: | 371935-74-9 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Identity determined by MS and NMR. |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (5mg/ml; warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | Protect from light. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
TRIM24 is an insulin-responsive regulator of P-bodies: W. Wei, et al.; Nat. Commun.
13, 3972 (2022),
Abstract;
A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils: B. Geering, et al.; Blood
117, 5953 (2011),
Abstract;
Full Text
Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia: F. Chiarini, et al.; Cancer Res.
69, 3520 (2009),
Abstract;
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma: Q.W. Fan, et al.; Cancer Cell
9, 341 (2006),
Abstract;
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling: Z.A. Knight, et al.; Cell
125, 733 (2006),
Abstract;
