Selective inhibitor of CDK1/cyclin B (IC50=20nM). Potent cytotoxin in tumor cells: IC50=5.3µM against MCF7 cells, IC50=11.1µM against K562 cells, IC50=3.0µM against CEM cells, IC50=6.3µM against HOS cells, and IC50=6.3µM against G361 cells.
Product Details
| Alternative Name: | 6-(2-Hydroxybenzylamino)-2(R)-[[1-hydroxymethyl)propyl]amino]-9-isopropylpurine |
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| Formula: | C19H26N6O2 |
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| MW: | 370.5 |
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| CAS: | 500735-47-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in DMSO, dimethyl formamide or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor: V. Krystof, et al.; Cell Mol. Life Sci.
62, 1763 (2005),
Abstract;
Synthesis and biological activity of olomoucine II: V. Krystof, et al.; Bioorg. Med. Chem. Lett.
12, 3283 (2002),
Abstract;
