Purvalanol B inhibits cyclin-dependent kinases with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Has also been shown to have anti-proliferative properties, mediated by p42/p44 MAPK.
Product Details
| Formula: | C20H25ClN6O3 |
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| MW: | 432.9 |
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| CAS: | 212844-54-7 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by EM-MS and NMR. |
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| Appearance: | White powder. |
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| Solubility: | Soluble in DMSO (112mg/ml) or ethanol (4mg/ml). |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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