Inhibitor of human CDK1 (IC50=4nM), CDK2/cyclin A (IC50=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC50=35nM), CDK4/cyclin D1 (IC50=850nM) as well as CDK5/p35 (IC50=75nM). More membrane permeable than purvalanol B.
Product Details
| Alternative Name: | 6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine |
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| Formula: | C19H25N6OCl |
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| MW: | 388.9 |
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| CAS: | 212844-53-6 |
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| Purity: | ≥99% (NMR) |
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| Appearance: | Off-white to yellow powder. |
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| Solubility: | Soluble in DMSO, methanol or dichloromethane. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Keep under inert gas. Keep cool and dry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Mitochondria localize to the cleavage furrow in mammalian cytokinesis: E.J. Lawrence, et al.; PLoS One
8, e72886 (2013),
Abstract;
Full Text
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons: E.A. Monaco, 3rd, et al.; Biochem. Pharmacol.
67, 1947 (2004),
Abstract;
Up-regulation of cdc2 protein during paclitaxel-induced apoptosis: P. Chadebech, et al.; Int. J. Cancer
87, 779 (2000),
Abstract;
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors: N.S. Gray, et al.; Science
281, 533 (1998),
Abstract;
