Very potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor.
Product Details
| Formula: | C18H26N2O2 |
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| MW: | 302.4 |
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| CAS: | 129075-73-6 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Off-white to light brown solid. |
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| Solubility: | Soluble in DMSO; slightly soluble in 100% ethanol; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stock solutions in DMSO are stable for up to 1 month when stored at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export: J.M. Rodríguez-Vargas, et al.; Cell Death Differ.
23, 2007 (2016),
Application(s): Cell treatment, MCF7 GFP-LC3 cells,
Abstract;
Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death: K. Moriwaki, et al.; Cell Death Dis.
6, e1636 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP-ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells: X. Feng, et al.; Int. J. Onc.
42, 749 (2013),
Abstract;
Full Text
Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors: L. Giovannelli, et al.; J. Cereb. Blood Flow Metab.
22, 697 (2002),
Abstract;
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia: F. Moroni, et al.; Cell Death Differ.
8, 921 (2001),
Abstract;
Post-treatment with an inhibitor of poly(ADP)-ribose polymerase attenuates cerebral damage in focal ischemia: K. Takahashi, et al.; Brain Res.
829, 46 (1999),
Abstract;
Full Text
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion: C. Szabo & V.L. Dawson; TIPS
19, 287 (1998), (Review),
Abstract;
Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats: H. Takahashi, et al.; J. Cereb. Blood Flow Metab.
17, 1137 (1997),
Abstract;
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia: M.J.L. Eliasson, et al.; Nat. Med.
3, 1089 (1997),
Abstract;
Dihydroisoquinolines: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase: M.J. Suto, et al.; Anticancer Drug Des.
6, 107 (1991),
Abstract;
