Very selective and potent neuronal nitric oxide synthase (nNOS/NOS I) inhibitor.
Product Details
| Alternative Name: | N5-(1-Imino-3-butenyl)-L-ornithine, L-VNIO |
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| Formula: | C9H17N3O2 . HCl |
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| MW: | 235.7 |
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| CAS: | 728944-69-2 |
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| Purity: | ≥95% (TLC) |
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| Appearance: | Off-white solid to clear film. |
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| Solubility: | Soluble in water, 100% ethanol (30mg/ml), DMSO (50mg/ml) or dimethyl formamide (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Very hygroscopic. Open only in anhydrous atmosphere. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The Endothelial Dysfunction Could Be a Cause of Heart Failure with Preserved Ejection Fraction Development in a Rat Model: T. Dupas, et al.; Oxid. Med. Cell. Longev.
2022, 7377877 (2022),
Abstract;
Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats: L.M. Yamaleyeva, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol.
292, R819 (2007),
Abstract;
Ischemia/reperfusion-induced death of cardiac myocytes: possible involvement of nitric oxide in the coordination of ATP supply and demand during ischemia: K. Kawahara, et al.; J. Mol. Cell Cardiol.
40, 35 (2006),
Abstract;
Neuronal nitric-oxide synthase inhibition facilitates adrenergic neurotransmission in rat mesenteric resistance arteries: Y. Hatanaka, et al.; J. Pharmacol. Exp. Ther.
316, 490 (2006),
Abstract;
Myocardial effects of nitric oxide, NO. Clinical and experimental evidence: C. Heymes, et al.; Bull. Acad. Natl. Med.
189, 893 (2005), [Article in French],
Abstract;
Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines: L.E. Bretscher, et al.; J. Biol. Chem.
278, 46789 (2003),
Abstract;
Full Text
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol.
58, 1026 (2000),
Abstract;
Full Text
N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase: B. R. Babu & O.W. Griffith; J. Biol. Chem.
273, 8882 (1998),
Abstract;
Full Text
General Literature References
Design of isoform-selective inhibitors of nitric oxide synthase: B.R. Babu & O.W. Griffith; Curr. Opin. Chem. Biol.
2, 491 (1998),
Abstract;
