Cell permeable antagonist of calmodulin. Inhibits Ca2+/calmodulin-dependent phosphodiesterase. Inhibits P-glycoprotein-mediated transport. Exhibits antibacterial, antitumor and nematocidal activities. Phytotoxic.
Product Details
| Alternative Name: | Cochliobolin A, Ophiobalin |
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| Formula: | C25H36O4 |
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| MW: | 400.6 |
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| Source: | Isolated from Bipolaris leersia MST-FP107. |
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| CAS: | 4611-05-6 |
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| RTECS: | RL1576000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Remodelling of Ca 2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells: T. Pick, et al.; Cell Calcium
99, 102473 (2021),
Abstract;
The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine: C. Chidley, et al.; eLife
5, e14601 (2016),
Application(s): Reagent, used to assess cytotoxicity effects,
Abstract;
Full Text
Herbicidal potential of ophiobolins produced by Drechslera gigantea: A. Evidente, et al.; J. Agric. Food Chem.
54, 1779 (2006),
Abstract;
Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products: N. Yoshida, et al.; Food Chem. Toxicol.
44, 2033 (2006),
Abstract;
Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis: S. Quetglas, et al.; EMBO J.
21, 3970 (2002),
Abstract;
Full Text
The biology of ophiobolins: T.K. Au, et al.; Life Sci.
67, 733 (2000), Review,
Abstract;
Microbial metabolites of ophiobolin A and antimicrobial evaluation of ophiobolins: E. Li, et al.; J. Nat. Prod.
58, 74 (1995),
Abstract;
Characterization of the interaction of ophiobolin A and calmodulin: P.C. Leung, et al.; Int. J. Biochem.
20, 1351 (1988),
Abstract;
Role of Calmodulin Inhibition in the Mode of Action of Ophiobolin A: P.C. Leung, et al.; Plant Physiol.
77, 303 (1985),
Abstract;
Full Text
Ophiobolin A. A natural product inhibitor of calmodulin: P.C. Leung, et al.; J. Biol. Chem.
259, 2742 (1984),
Abstract;
Full Text
The constitution of cochliobolin: L. Canonica, et al.; THL 7, 1211 (1966),
The structure of ophiobolin, a C25 terpenoid having a novel skeleton: S. Nozoe, et al.; JACS
87, 4968 (1965),
Abstract;
