Potent and selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II).
Product Details
| Alternative Name: | 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine . HCl |
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| Formula: | C5H10N2S . HCl |
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| MW: | 166.7 |
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| CAS: | 1121-91-1 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells: S.O. Cho, et al.; Dig. Dis. Sci.
55, 988 (2010),
Abstract;
Potential role of inducible nitric oxide synthase in the sleep-wake states occurrence in old rats: P. Clement, et al.; Neuroscience
135, 347 (2005),
Abstract;
Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy: B.T. Alexander, et al.; Hypertension
39, 586 (2002),
Abstract;
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol.
58, 1026 (2000),
Abstract;
Full Text
Role of iNOS in the vasodilator responses induced by L-arginine in the middle cerebral artery from normotensive and hypertensive rats: A.M. Briones, et al.; Br. J. Pharmacol.
126, 111 (1999),
Abstract;
Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition: M.A. Rudd, et al.; Am. J. Physiol.
277, H732 (1999),
Abstract;
Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus: R.L. Rairigh, et al.; J. Clin. Invest.
101, 15 (1998),
Abstract;
In vivo pharmacological evaluation of two novel type II (inducible) nitric oxide synthase inhibitors: W.R. Tracey, et al.; Can. J. Physiol. Pharmacol.
73, 665 (1995),
Abstract;
Novel potent and selective inhibitors of inducible nitric oxide synthase: M. Nakane, et al.; Mol. Pharmacol.
47, 831 (1995),
Abstract;
