Selective cell permeable inhibitor of PKCζ. Activates eNOS (NOS III) through Akt phosphorylation and can be considered as a nitric oxide production activator in endothelial cells.
Product Details
| Alternative Name: | Protein kinase Cζ pseudosubstrate, PKCζ (113-125) (myristoylated) |
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| Sequence: | N-Myristoyl-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH |
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| Formula: | C90H154N30O17 |
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| MW: | 1928.4 |
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| Formulation: | Counter Ion: TFA |
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| Peptide Content: | ≥60% |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water, DMSO or water-methanol (50:50) . |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Desmin aggrephagy in rat and human ischemic heart failure through PKCζ and GSK3β as upstream signaling pathways: M. Bouvet, et al.; Cell Death Discov.
7, 41410 (2021),
Abstract;
The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor: A. Khodorova, et al.; Neuroscience
340, 384 (2017),
Abstract;
Full Text
The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages: A.W. Lee; PLoS One
6, e25580 (2011),
Abstract;
Full Text
Peptides modified by myristoylation activate eNOS in endothelial cells through Akt phosphorylation: K. Krotova, et al.; Br. J. Pharmacol.
148, 732 (2006),
Abstract;
