Replaces Prod. #: ALX-210-907
Product Details
| Alternative Name: | Mitochondrial fission 1 |
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| Host: | Rabbit |
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| Isotype: | IgG |
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| Immunogen: | Synthetic peptide surrounding aa 143 of human Fis1. |
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| UniProt ID: | Q9Y3D6 |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (1-4 µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Purity Detail: | Affinity purified. |
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| Formulation: | Liquid. In PBS containig 0.5% BSA, 0.01% thimerosal and 30% glycerol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | The human Fis1, mitochondrial fission 1, is a novel molecule that was discovered as part of the mammalian fission machinery. Fis1 has been suggested to play a role in regulation of the fission processes that might be involved in apoptotic mechanisms. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of Fis1 pAb (Prod. No. ALX-210-1037) with Jurkat cell lysates.
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Product Literature References
The fasting-feeding metabolic transition regulates mitochondrial dynamics: M. Castro-Sepúlveda, et al.; FASEB J.
35, e21891 (2021),
Abstract;
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats: J.C.B. Ferreira, et al.; Nat. Commun.
10, 329 (2019),
Abstract;
Full Text
Fis1 deficiencies differentially affect mitochondrial quality in skeletal muscle: Z. Zhang, et al.; Mitochondrion
49, 217 (2019),
Abstract;
Full Text
Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway: Y. Yu, et al.; Free Radic. Biol. Med.
112, 397 (2017),
Application(s): Western Blot,
Abstract;
Severe encephalopathy associated to pyruvate dehydrogenase mutations and unbalanced coenzyme Q10 content: C. Asencio, et al.; Eur. J. Hum. Genet.
24, 367 (2016),
Application(s): Western Blot,
Abstract;
Sprague Dawley rats: a model of successful heart aging: D. Capitanio, et al.; EuPA Open Proteom.
12, 22 (2016),
Application(s): Immunoblotting,
Abstract;
Full Text
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice: M. Yue, et al.; Neurobiol. Dis.
78, 172 (2015),
Application(s): Western Blot,
Abstract;
