Replaces Prod. #: BML-KC150
Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker.
Product Details
| Sequence: | H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
(Disulfide bonds between Cys1-Cys11and Cys3-Cys15) |
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| Formula: | C79H131N31O24S4 |
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| MW: | 2027.3 |
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| Source: | Synthetic. |
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| CAS: | 24345-16-2 |
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| MI: | 14: 725 |
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| RTECS: | CD6899900 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Lyophilized. |
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| Solubility: | Soluble in 0.05M acetic acid (5mg/ml); slightly soluble in water (1mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
GnRH-induced Ca2+ oscillations and rhythmic hyperpolarizations of pituitary gonadotropes.: A. Tse et al.; Science
255, 462 (1992),
Abstract;
Potassium channel toxins: P.N. Strong; Pharmacol. Ther.
46, 137 (1990),
Abstract;
Toxins in the characterization of potassium channels: N.A. Castle, et al.; TINS
12, 59 (1989), (Review),
Abstract;
Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle.: A.L. Blatz & K. L. Magleby; Nature
323, 718 (1986),
Abstract;
Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor.: M. Hugues et al.; PNAS
79, 1308 (1982),
Abstract;
