Potent, cell permeable cysteine thioether displaying anti-mitotic and anti-tumor properties. Inhibits mitosis by blocking basal and microtubule-activated ATPase activities of the mitotic kinesin Eg5 (IC50=1µM and 140nm). Induces mitotic arrest in HeLa cells (IC50=700nM) and inhibits the growth of NCI tumor cell line panel (GI50=1.31µM).
Product Details
| Alternative Name: | NSC 83265, STLC |
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| Formula: | C22H21NO2S |
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| MW: | 363.5 |
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| CAS: | 2799-07-7 |
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| RTECS: | AY7710000 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO or acetic acid. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A mitotic chromatin phase transition prevents perforation by microtubules: M.W.G. Schneider, et al.; Nature
609, 183 (2022),
Abstract;
A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression: E. Pangou, et al.; Cell Rep.
35, 109129 (2021),
Abstract;
S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression: D.A. Skoufias, et al.; J. Biol. Chem.
281, 17559 (2006),
Abstract;
Full Text
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities: S. DeBonis, et al.; Mol. Cancer Ther.
3, 1079 (2004),
Abstract;
Full Text
