Product Details
Alternative Name: | GOSR2, golgi SNAP receptor complex member |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to a portion of rat membrin. |
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UniProt ID: | O35165 |
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GenBank ID: | U91539 |
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Source: | Purified from rabbit serum. |
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Species reactivity: | Human, Mouse, Rat Bovine, Chicken, Dog, Drosophila, Hamster, Monkey, Porcine, Rabbit, Sheep
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Applications: | IHC (PS), WB
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Recommended Dilutions/Conditions: | Western Blot (2µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~27kDa by Western blot. Cited applications include Immunofluorescence. |
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Purity Detail: | Peptide immunoaffinity purified. |
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Formulation: | Liquid. In borate buffered saline, pH 8.4, containing 25mM sodium borate, 100mM boric acid, 75mM sodium chloride, 5mM EDTA (disodium salt). |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Membrin, also known as GS27 (Golgi SNARE of 27K), is an integral membrane protein present on the surface of the Golgi apparatus. GS27 is a member of a protein complex that consists of cis-Golgi vesicle receptor syntaxin 5 and GS28, v-SNARE rbet1 and Rsec22, and Rsly1. These complexes are postulated to direct the fusion of ER-derived vesicles with vesicular tubular cluster (VTC), and the fusion of VTCs to form cis-Golgi compartment. |
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Technical Info/Product Notes: | Recommended by the Human Protein Atlas Organization for IHC (Ensembl No. ENSG00000108433). |
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Regulatory Status: | RUO - Research Use Only |
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Immunohistochemistry analysis of human liver tissue stained with Membrin, pAb at 10µg/ml.
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Product Literature References
Data supporting ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion: K. Suga, et al.; Data Brief
5, 782 (2015),
Application(s): Western blot,
Abstract;
ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion: K. Suga, et al.; Exp. Cell Res.
332, 11 (2015),
Application(s): Western Blotting,
Abstract;
Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells: L. Haataja, et al.; J. Biol. Chem.
288, 1896 (2013),
Application(s): Immunofluorescence of rat INS1 cells,
Abstract;
Full Text
Segregation of the Qb-SNAREs GS27 and GS28 into Golgi vesicles regulates intra-Golgi transport: A. Fusella, et al.; Traffic.
14, 568 (2013),
Application(s): Western blot using hamster CHO cells,
Abstract;
Full Text