| ADI-KAS-MA013-E | 100 µl | 328.00 USD |  |
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| Alternative Name: | MAP3K3, MEK kinase 3 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of mouse MEKK3. |
| UniProt ID: | Q61084 |
| GenBank ID: | U43187 |
| Source: | Whole rabbit serum. |
| Species reactivity: | Human, Mouse, Rat Dog, Drosophila, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus |
| Applications: | IHC (PS), WB |
| Recommended Dilutions/Conditions: | Western Blot (1:5,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Formulation: | Liquid. Whole rabbit serum. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | MEKKs (Mitogen activated protein kinase kinase kinases) are serine-threonine kinases that act as the first tier of cellular MAP kinase pathways by activation of MAP/ERK kinases, or MEKs. Many enzymes with MEKK activity have been identified, including MEKK1-4, Raf, MLK3, TAK, and DLK. MEKKs generally display little similarity outside of their catalytic kinase domains. MEKK1-4 are nearly 50% identical within their catalytic domains, and are known to regulate Erk, Jnk, and p38 MAP kinase pathways. MEKK2 and MEKK3 bind MEK5 via conserved PB1 domains, leading to downstream activation of Erk5. |
| Regulatory Status: | RUO - Research Use Only |
