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CD36 (human), (recombinant)

 
ENZ-PRT170-0010 10 µg 199.00 USD
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Product Specification

Alternative Name:SCARB3, GP3B, GP4, Platelet glycoprotein 4
 
MW:~47.5 kDa
 
Source:Produced in HEK 293 cells.
 
UniProt ID:P16671
 
Formulation:Lyophilized from 0.22µm filtered solution in PBS, pH 7.4. Generally 5-8% mannitol or trehalose is added as a protectant before lyophilization.
 
Purity:≥95% (SDS-PAGE)
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-20°C
 
Scientific Background:CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). It also may function as a cell adhesion molecule. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. It also binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. It also serves as a receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a co-receptor for TLR4-TLR6 heterodimer, it promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, it rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-κ-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MyD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL-1B secretion.
 

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