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Erlotinib . HCl

EGFR tyrosine kinase auto-phosphorylation inhibitor
 
ENZ-CHM157-0005 5 mg 51.00 USD
 
ENZ-CHM157-0050 50 mg 153.00 USD
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Erlotinib inhibits EGFR tyrosine kinase auto-phosphorylation. Studies in cell lines and enzyme assays have shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl. It has an IC50 of 2 nM against EGFR. It is >1000-fold more sensitive for EGFR than for c-Src or v-Abl.

Product Specification

Alternative Name:OSI774, CP-358774, NSC718781
 
Formula:C22H23N3O4 . HCl
 
MW:429.9
 
CAS:183319-69-9
 
Purity:≥95% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:Yellow powder.
 
Solubility:Soluble in DMSO (3mg/ml) or ethanol (<1mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
ENZ-CHM157 structure
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ENZ-CHM157 structure

Product Literature References

Genome-Wide siRNA Screen for Anti-Cancer Drug Resistance in Adherent Cell Lines: E.C. de Bruin, et al.; Bio-Protocol 5, (2015), Application(s): Cell Culture, Full Text

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