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TIM-3 monoclonal antibody (1B10)

 
ENZ-ABS702-0100 100 µg 457.00 USD
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Product Specification

Alternative Name:CD366, TIMD3
 
Clone:1B10
 
Host:Mouse
 
Isotype:IgG1κ
 
Immunogen:Extracellular domain of human TIM-3.
 
UniProt ID:Q8TDQ0
 
Species reactivity:Human
 
Applications:Flow Cytometry, ICC, IF, IHC (PS), WB
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells. TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice. Blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth.
 

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