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United States 

TROP2 (human) monoclonal antibody (01)

 
ENZ-ABS380-0100 100 µg 230.00 USD
 

Product Specification

Alternative Name:Tumor associated calcium signal transducer 2, GA733-1, M1S1, TACSTD2
 
Clone:01
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human TROP2 extracellular domain.
 
UniProt ID:P09758
 
Species reactivity:Human
 
Crossreactivity:Does not cross-react with mouse or rat TROP2.
 
Applications:ELISA, Flow Cytometry, IHC (PS)
 
Recommended Dilutions/Conditions:ELISA (This antibody can be used at 0.5-1 µg/mL with the appropriate secondary reagents to detect human TROP2. The detection limit for human TROP2 is 0.039 ng/well)
Flow Cytometry (0.5-2 µg/mL)
Immunohistohemistry (paraffin sections, 5-15 µg/mL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. 0.2 µM filtered solution in PBS containing 5% trehalose. Preservative free.
 
Handling:Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%) It is toxic to cells and should be disposed of properly. Avoid freeze-thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Trop-2 (tumor-associated calcium signal transducer 2) is a 46-48kDa cell surface glycoprotein that acts as a calcium signal transducer. The molecule is expressed at high levels in human throphoblasts and overexpressed on a large variety of human carcinomas (including breast, colon, lung and prostate cancers). As an example, Trop-2 is among the most highly overexpressed genes in primary ovarian serous papillary tumors compared to normal ovarian epithelium and in in colon tumors compared with normal mucosa. Trop-2 is homologous to Trop-1 and both are homologous to serum IGF-II-binding proteins. The specific role of Trop-2 in normal and tumor cells is not fully defined, but accumulating evidence suggests a regulatory role in the growth of carcinoma cells. Furthermore there is data supporting the hypothesis that Trop-2 is involved in tumor invasion and metastasis. Indeed, TROP2 is one of the cancer-related genes that correlates with biological aggressiveness and poor prognosis of colorectal cancer.
 

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