| Alternative Name: | Repulsive guidance molecule C, Hemojuvelin, Hemochromatosis type 2 protein, HFE2, HJV |
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| Clone: | 1D7 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant human RGMC (aa 36-398). |
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| UniProt ID: | Q6ZVN8 |
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| Source: | Purified from ascites. |
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| Species reactivity: | Human
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| Applications: | ELISA, Flow Cytometry, IP, WB
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Scientific Background: | The RGMC (also called Hemojuvelin) is a GPI-anchored protein involved in iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated. |
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| Regulatory Status: | RUO - Research Use Only |
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