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TSQ (ultra pure)

Zinc dye
ENZ-52153 25 mg 100.00 USD
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TSQ is one of the most efficient membrane-permeable fluorescent probes for zinc (II). It is selective for Zn (II) in the presence of physiological concentrations of Ca (II) and Mg (II) ions. Fluorescence of Zinquin ethyl ester is enhanced upon binding Zn (II), but the probe does not demonstrate a shift or change in emission wavelength. TSQ forms a largely insoluble 2:1 (Ligand-Metal) complex with zinc and emits blue light upon excitation at 365 nanometers. TSQ has been extensively applied to study Zn (II) in mossy fibers of the hippocampus. TSQ has been used to monitor intracellular zinc fluxes associated with apoptosis as well. Wavelength Maxima: Excitation 344nm, Emission 385nm

Product Specification

Alternative Name:N-(6-Methoxy-8-quinolyl)-p-toluenesulfonamide
Purity:≥98% (HPLC)
Solubility:Soluble in DMSO.
Long Term Storage:-20°C
Use/Stability:Stable for at least one year after receipt when stored as recommended.
Handling:Protect from light. Keep cool and dry.
Technical Info/Product Notes:

This product is a member of the CELLESTIAL® product line, reagents and assay kits comprising fluorescent molecular probes that have been extensively benchmarked for live cell analysis applications. CELLESTIAL® reagents and kits are optimal for use in demanding imaging applications, such as confocal microscopy, flow cytometry and HCS, where consistency and reproducibility are required.

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Product Literature References

Luteolin protects against reactive oxygen species-mediated cell death induced by zinc toxicity via the PI3K-Akt-NF-κB-ERK-dependent pathway: F. Zhou, et al.; J. Neurosci. Res. 89, 1859 (2011), Abstract;
Histochemical and histofluorescence tracing of chelatable zinc in the developing mouse: Y.B. Nitzan, et al.; J. Histochem. Cytochem. 52, 529 (2004), Abstract;
Intracellular zinc fluxes associated with apoptosis in growth plate chondrocytes: G.R. Sauer, et al.; J. Cell Biochem. 88, 954 (2003), Abstract;

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