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Z-Leu-Leu-Glu-AMC

 
BML-ZW9345-0005 5 mg 163.00 USD
 
BML-ZW9345-0050 50 mg 1,275.00 USD
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Replaces Prod. #: ALX-260-086

Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole.

Product Specification

Alternative Name:Z-LLE-AMC, Proteasome substrate II (fluorogenic)
 
Sequence:Z-LLE-AMC (AMC=7-Amino-4-methylcoumarin)
 
Formula:C35H44N4O9
 
MW:664.75 Da
 
Purity:≥95% (HPLC)
 
Appearance:Lyophilized. Off white powder.
 
Solubility:Soluble in dimethylformamide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy: J. Li, et al.; J. Mol. Cell. Cardiol. 102, 53 (2016), Abstract;
Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation: W.H. Choi, et al.; Nat. Commun. 7, 10963 (2016), Application(s): Western blot, Abstract;
Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease: R. Velazquez, et al.; Mol. Neurodegener. 11, 52 (2016), Application(s): Proteasome activity, brain homogenate, Abstract; Full Text
The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies: S. Bhattarai, et al.; J. Autoimmun. 75, 118 (2016), Application(s): Measurement of CT-L and CL proteasome activity, Abstract;
FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing: Z. Wang, et al.; Cell Death Dis. 6, e1815 (2015), Application(s): Proteasome activity assays, Abstract; Full Text
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts: A.D. Sklirou, et al.; Redox Biol. 5, 205 (2015), Application(s): Fluorescent detection, Abstract;
The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells: M. Hamouda, et al.; Oncotarget 5, 6252 (2014), Application(s): Analysis of velcade resistant multiple myeloma human cells by WB, Assay, Abstract; Full Text
Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells: H. Jiang, et al.; Cell Death Dis. 4, e761 (2013), Application(s): Fluorogenic substrate for kinetics assay of 20S proteasome, Abstract; Full Text

General Literature References

Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome.: S. Tsubuki et al.; Biochem. Biophys. Res. Commun. 196, 1195 (1993), Abstract;
Enzymatic changes of the bovine pituitary multicatalytic proteinase complex, induced by magnesium ions.: M.E. Pereira et al.; Arch. Biochem. Biophys. 294, 1 (1992), Abstract;
Chemical modification of the bovine pituitary multicatalytic proteinase complex by N-acetylimidazole. Reversible activation of casein hydrolysis.: B. Yu et al.; J. Biol. Chem. 266, 17396 (1991), Abstract;
Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex.: M. Orlowski et al.; Biochemistry 30, 5999 (1991), Abstract;

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