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BML-ZW9345-0005 5 mg 166.00 USD
BML-ZW9345-0050 50 mg 1,301.00 USD
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Replaces Prod. #: ALX-260-086

Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole.

Product Specification

Alternative Name:Z-LLE-AMC, Proteasome substrate II (fluorogenic)
Sequence:Z-LLE-AMC (AMC=7-Amino-4-methylcoumarin)
MW:664.75 Da
Purity:≥95% (HPLC)
Appearance:Lyophilized. Off white powder.
Solubility:Soluble in dimethylformamide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C

Product Literature References

A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis: S.L. Dong, et al.; Emerg. Microbes Infect. 6, e105 (2017), Abstract; Full Text
A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress: K. Ben Younes, et al.; BMC Cancer 17, 538 (2017), Abstract; Full Text
Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy: J. Li, et al.; J. Mol. Cell. Cardiol. 102, 53 (2016), Abstract;
Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation: W.H. Choi, et al.; Nat. Commun. 7, 10963 (2016), Application(s): Western blot, Abstract;
Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease: R. Velazquez, et al.; Mol. Neurodegener. 11, 52 (2016), Application(s): Proteasome activity, brain homogenate, Abstract; Full Text
The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies: S. Bhattarai, et al.; J. Autoimmun. 75, 118 (2016), Application(s): Measurement of CT-L and CL proteasome activity, Abstract;
FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing: Z. Wang, et al.; Cell Death Dis. 6, e1815 (2015), Application(s): Proteasome activity assays, Abstract; Full Text
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts: A.D. Sklirou, et al.; Redox Biol. 5, 205 (2015), Application(s): Fluorescent detection, Abstract;
The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells: M. Hamouda, et al.; Oncotarget 5, 6252 (2014), Application(s): Analysis of velcade resistant multiple myeloma human cells by WB, Assay, Abstract; Full Text
Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells: H. Jiang, et al.; Cell Death Dis. 4, e761 (2013), Application(s): Fluorogenic substrate for kinetics assay of 20S proteasome, Abstract; Full Text

General Literature References

Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome.: S. Tsubuki et al.; Biochem. Biophys. Res. Commun. 196, 1195 (1993), Abstract;
Enzymatic changes of the bovine pituitary multicatalytic proteinase complex, induced by magnesium ions.: M.E. Pereira et al.; Arch. Biochem. Biophys. 294, 1 (1992), Abstract;
Chemical modification of the bovine pituitary multicatalytic proteinase complex by N-acetylimidazole. Reversible activation of casein hydrolysis.: B. Yu et al.; J. Biol. Chem. 266, 17396 (1991), Abstract;
Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex.: M. Orlowski et al.; Biochemistry 30, 5999 (1991), Abstract;

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