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Docetaxel

Ultra-pure; stabilizes microtubules
 
BML-T129-0005 5 mg 80.00 USD
 
BML-T129-0025 25 mg 342.00 USD
 
BML-T129-0250 250 mg 1,162.00 USD
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Docetaxel is taxane-type antineoplastic agent structurally similar to taxol. It reversibly binds to polymerized tubulin inhibiting depolymerization. It induces apoptosis in a large number of tumor cells and is a clinically important anticancer agent.

Product Specification

Alternative Name:Taxotere
 
Formula:C43H53NO14
 
MW:807.9
 
CAS:114977-28-5
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
BML-T129 structure
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BML-T129 structure

Product Literature References

Docetaxel in the management of prostate cancer: current standard of care and future directions: S. De Dosso & D.R. Berthold; Expert. Opin. Pharmacother. 9, 1969 (2008), Abstract;
Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells: F. Fabbri, et al.; J. Cell Physiol. 217, 494 (2008), Abstract;
Reversal of multidrug resistance by synthetic and natural compounds in drug-resistant MCF-7 cell lines: M.D. Kars, et al.; Chemotherapy 54, 194 (2008), Abstract;
RPN2 gene confers docetaxel resistance in breast cancer: K. Honma, et al.; Nat. Med. 14, 939 (2008), Abstract;
Sunitinib malate (SU-11248) alone or in combination with low-dose docetaxel inhibits the growth of DU-145 prostate cancer xenografts: A. Cumashi, et al.; Cancer Lett. 270, 229 (2008), Abstract;

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