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Cytochalasin B

Ultra-pure; inhibits actin polymerization
 
BML-T108-0005 5 mg 112.00 USD
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Replaces Prod. #: ALX-380-012

Cytochalasin B is a cell-permeable fungal toxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. It causes the disruption of actin filaments and inhibition of actin polymerization. It also inhibits monosaccharide transport across cell membranes. inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.

Product Specification

Formula:C29H37NO5
 
MW:479.6
 
Source:Isolated from Drechslera dematoidea
 
CAS:14930-96-2
 
Purity:≥98% (HPLC, TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in methanol or DMSO (20mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
BML-T108 structure
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BML-T108 structure

Product Literature References

Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation: A.M. George Thompson, et al.; Sci. Rep. 6, 24240 (2016), Application(s): Cell culture, Abstract;
The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants: H.B. Pinkofsky et al.; Life. Sci. 66, 271 (2000), Abstract;
Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping: P.A. Theodoropoulos et al.; Biochem. Pharmacol. 47, 1875 (1994), Abstract;
Effect of cytochalasin B on glucose uptake, utilization, oxidation and insulinotropic action in tumoral insulin-producing cells: W.J. Malaisse; Cell. Biochem. Funct. 5, 183 (1987), Abstract;
Effects of cytochalasin and phalloidin on actin: J.A. Cooper; J. Cell. Biol. 105, 1473 (1987), Abstract;
Effects of cytochalasin B on endocytosis and exocytosis: P. Davies & A.C. Allison; Front. Biol. 46, 143 (1978), Abstract;
Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out): J.W. Sanger & H. Holtzer; PNAS 69, 253 (1972), Abstract;
Cytochalasin B: inhibition of glucose and glucosamine transport: R.D. Ebstensen & P.G. Plagemann; PNAS 69, 1430 (1972), Abstract;

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