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Dihydrosphingosine, D-erythro

Sphingosine precursor



BML-SL125-0010	10 mg	82.00 USD

BML-SL125-0050	50 mg	347.00 USD
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Replaces Prod. #: ALX-306-008

Biosynthetic precursor of sphingosine. Inhibitor of protein kinase C (PKC). Blocks phospholipases A₂ (PLA2) and the D-sphingosine precursor.

Product Details

Alternative Name:	D-erythro-Sphingosine, Dihydro-, Sphinganine

Formula:	C₁₈H₃₉NO₂

MW:	301.5

CAS:	764-22-7

Purity:	≥98% (TLC)

Appearance:	White to off-white solid.

Solubility:	Soluble in 100% ethanol (25mg/ml, warm) or DMSO (25mg/ml, warm).

Shipping:	Blue Ice

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Technical Info/Product Notes:	Note: Product is not sterile.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases: T. Narita, et al.; Sci. Rep. 6, 25469 (2016), Application(s): Cell culture, Abstract; Full Text

Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60): B.Y. Yung, et al.; BBRC 199, 888 (1994), Abstract;

Glucocorticoid stimulation of amnion cell prostaglandin synthesis: suppression by protein kinase C inhibitors and independence of phorbol ester-sensitive protein kinase C: T. Zakar, et al.; Biochim. Biophys. Acta 1136, 161 (1992), Abstract;

Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine: R.C. Franson, et al.; Biochim. Biophys. Acta 1136, 169 (1992), Abstract;

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds: A.H. Merrill, Jr., et al.; Biochemistry 28, 3138 (1989), Abstract;

Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s): A.H. Merrill & E. Wang; J. Biol. Chem. 261, 3764 (1986), Abstract;

In vivo studies on the introduction of the 4-t-double bond of the sphingenine moiety of rat brain ceramides: D.E. Ong & R.N. Brady; J. Biol. Chem. 248, 3884 (1973), Abstract;