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Proteasome 20S β1 subunit monoclonal antibody (MCP421)

 
BML-PW8140-0025 25 µl 108.00 USD
 
BML-PW8140-0100 100 µl 345.00 USD
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Product Specification

Alternative Name:Proteasome subunit β type-6, Macropain δ chain, Proteasome subunit Y
 
Clone:MCP421
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Dinitrophenylated proteasomes.
 
UniProt ID:P28072
 
Gene/Protein Identifier:PSMB6 (gene name)
 
Species reactivity:Human
Rabbit, Yeast
 
Specificity:Recognizes the β1 subunit of the 20S proteasome.
 
Applications:IHC, WB
 
Purity Detail:Protein G-affinity purified ascites.
 
Formulation:Liquid. In PBS containing 10mM sodium azide.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:Various systems for the nomenclature of the proteasome subunits have been established. This may be a source of confusion as the system on UniProt differs from "standard" nomenclature as described in the literature. The UniProt ID and Gene Name will help to clearly identify the proteins.
 
BML-PW8140 WB
Western blot analysis of Proteasome 20S β1 subunit, mAb (MCP421) (Prod. No. BML-PW8140): Lane 1: MW marker, Lane 2: HeLa (Prod. No. ADI-LYC-HL100), Lane 3: HeLa S100 fraction (Prod. No. BML-SW8750), Lane 4: 3T3 (Prod. No. ADI-LYC-3T100).
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BML-PW8140 WB

Product Literature References

Detection of active proteasome structures in brain extracts: proteasome features of August rat brain with violations in monoamine metabolism: P.A. Erokhov, et al.; Oncotarget 8, 70695 (2017), Abstract; Full Text
Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts: A. Desvergne, et al.; Free Radic. Biol. Med. 94, 195 (2016), Application(s): Western blot, Abstract;
Skeletal muscle myotubes in severe obesity exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux: L.M. Bollinger, et al.; Obesity (Silver Spring) 23, 1185 (2015), Application(s): Western Blot, Abstract; Full Text
SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes: T. Homma, et al.; Arch. Biochem. Biophys. 583, 65 (2015), Application(s): Immunoblotting, Abstract;
The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells: M. Hamouda, et al.; Oncotarget 5, 6252 (2014), Application(s): Analysis of velcade resistant multiple myeloma human cells by WB, Assay, Abstract; Full Text
Purification and separation of the 20S immunoproteasome from the constitutive proteasome and identification of the subunits by LC-MS: V. Dechavanne, et al.; Protein Exp. Purif. 87, 100 (2013), Application(s): Western blot, Abstract;
Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy: P. Balsas, et al.; Leuk. Res. 36, 212 (2012), Application(s): Western blot, Abstract;

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