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N-Acetyl-Leu-Leu-Methional

Calpain inhibitor
 
BML-PI100-0005 5 mg 92.00 USD
 
BML-PI100-0025 25 mg 351.00 USD
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Replaces Prod. #: ALX-260-038

Cell-permeable, peptide aldehyde inhibitor of calpain and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6nM) and cathepsin B (Ki=100nM).

Product Specification

Alternative Name:ALLM, Ac-LLM-CHO, Calpain inhibitor II
 
Sequence:N-Acetyl-Leu-Leu-Met-H
 
Formula:C19H35N3O4S
 
MW:401.6
 
CAS:110115-07-6
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:5mg/ml soluble in 100% ethanol, methanol or DMSO
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
BML-PI100 structure
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BML-PI100 structure

General Literature References

Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain.: M.E. Figueiredo-Pereira et al.; J. Neurochem. 62, 1989 (1994), Abstract;
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids.: M. Orlowski et al.; Biochemistry 32, 1563 (1993), Abstract;
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex.: A. Vinitsky et al.; Biochemistry 31, 9421 (1992), Abstract;
Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.: T. Sasaki et al.; J. Enzyme Inhib. 3, 195 (1990), Abstract;

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