N-Acetyl-Leu-Leu-Methional

Calpain inhibitor



BML-PI100-0005	5 mg	79.00 USD

BML-PI100-0025	25 mg	315.00 USD

Replaces Prod. #: ALX-260-038

Cell-permeable, peptide aldehyde inhibitor of calpain and other neutral cysteine proteases. Potent inhibitor of cathepsin L (K_i=0.6nM) and cathepsin B (K_i=100nM).

Product Specification

Alternative Name:	ALLM, Ac-LLM-CHO, Calpain inhibitor II

Formula:	C₁₉H₃₅N₃O₄S

MW:	401.57 Da

Purity:	95% (HPLC)

Appearance:	White powder.

Sequence:	N-Acetyl-Leu-Leu-Met-H

CAS:	136632-32-1

Solubility:	Soluble in DMSO (25 mg/ml) and ethanol (25 mg/ml).

Long Term Storage:	-20°C

Background / Technical Information:	Please click here for the comprehensive product datasheet.

General Literature References

Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain.: M.E. Figueiredo-Pereira et al.; J. Neurochem. 62, 1989 (1994), Abstract;

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids.: M. Orlowski et al.; Biochemistry 32, 1563 (1993), Abstract;

Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex.: A. Vinitsky et al.; Biochemistry 31, 9421 (1992), Abstract;

Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.: T. Sasaki et al.; J. Enzyme Inhib. 3, 195 (1990), Abstract;