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OMNICATHEPSIN® fluorogenic substrate

 
BML-P139-0010 10 mg 62.00 USD
 
BML-P139-0050 50 mg 221.00 USD
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Replaces Prod. #: ALX-260-131

Fluorogenic substrate cleaved by plasma kallikrein and kallikrein 8, but not plasmin; by papain; and by most cathepsins (cathepsins B, C/DPP-I, F, K/O2, L, L2/V, O, S, and X/Z). Ex.: 380 nm, Em.: 460 nm, although the following Ex/Em can also be used: 355,375/440,450. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

Product Specification

Alternative Name:Z-FR-AMC, Z-Phe-Arg-AMC
 
Sequence:Z-FR-AMC, Z-Phe-Arg-AMC . HCl [Z=Cbz=Benzyloxycarbonyl; AMC=7-amino-4-methylcoumarin]
 
Formula:C33H36N6O6 . HCl
 
MW:649.2
 
CAS:65147-22-0
 
Purity:≥99%
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Evaluation of trypanocidal activity of combinations of anti-sleeping sickness drugs with cysteine protease inhibitors: D. Steverding, et al.; Exp. Parasitol. 151, 28 (2015), Application(s): Assay, Abstract;
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract;

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