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Zebularine

Dnmt inhibitor
 
BML-GR344-0010 10 mg 116.00 USD
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Zebularine is a DNA methylation inhibitor which acts by forming a covalent complex with DNMT. It displays antiangiogenic activity and markedly inhibits vessel formation in different tumor models. It reactivates silenced E-cadherin and potentiates the effects of other epigenetic therapeutics such as vorinistat. Induces differentiation of mesenchymal cells into cardiomyocytes. Inhibits cytidine deaminase.

Product Specification

Alternative Name:1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
 
Formula:C9H12N2O5
 
MW:228.2
 
CAS:3690-10-6
 
Purity:≥98% (TLC)
 
Purity Detail:TLC: 30% Methanol/methylene chloride + 1% H2O, Rf = 0.3
 
Appearance:Off-white solid.
 
Solubility:Soluble in water (>25 mg/ml) or DMSO (>25 mg/ml).
 
Application Notes:Can be used for in vitro or cell based studies.
 
Shipping:Ambient
 
Short Term Storage:-20°C
 
Long Term Storage:-20°C
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
BML-GR344
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BML-GR344

Product Literature References

Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells: M. Billam, et al.; Breast Cancer Res. Treat. Inst. 120, 581 (2010), Abstract;
Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells: S.P. Rao, et al.; Mol. Cancer 6, 3 (2007), Abstract;
Angiostatic activity of DNA methyltransferase inhibitors: D.M.E.I. Hellebrekers, et al.; Mol. Cancer Ther. 5, 467 (2006), Abstract;
Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases: L. Zhou, et al.; J. Mol. Biol. 321, 591 (2002), Abstract;

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