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PRIMA-1

p53 activator
 
BML-GR333-0005 5 mg 68.00 USD
 
BML-GR333-0025 25 mg 251.00 USD
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Replaces Prod. #: ALX-270-310

Novel cell-permeable p53 reactivating agent. Restores sequence-specific DNA binding and the active conformation to mutant p53 (in 13 of 14 p53 mutants tested) in vitro and in living cells. Induces apoptosis in human tumor cell lines and displays antitumor activity in mice.

Product Specification

Alternative Name:2,2-bis(Hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one, 2,2-bis(Hydroxymethyl)-3-quinuclidinone
 
Formula:C9H15NO3
 
MW:185.2
 
CAS:5608-24-2
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble at 25 mg/ml in ethanol, 100% DMSO, and DMF. Soluble at 10 mg/ml in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year.  Store stock solutions at-20°C for up to 3 months. Storage of aqueous solutions is not recommended.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
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Product Literature References

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound: V.J. Bykov, et al.; Nat. Med. 8, 282 (2002), Abstract;

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