Selective estrogen receptor ERβ agonist displaying 70-fold greater selectivity over ERα(EC50 = 0.85 and 66nM, respectively). It displays neuroprotective activity in various in vitro and in vivo models.
Product Details
| Alternative Name: | Diarylpropionitrile, 2,3-bis(4-Hydroxyphenyl)-propionitrile |
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| Formula: | C15H13NO2 |
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| MW: | 239.3 |
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| CAS: | 1428-67-7 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| MeltingPoint: | 197-199°C |
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| Solubility: | Soluble in DMSO (10mg/ml) or 100% ethanol (1.5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at-20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Neuroprotective properties of selective estrogen receptor agonists in cultured neurons: M. Cordey & C.J. Pike; Brain Res.
1045, 217 (2005),
Abstract;
Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia: H.V. Carswell, et al.; Am. J. Physiol. Heart Circ. Physiol.
287, H1501 (2004),
Abstract;
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues: M.J. Meyers, et al.; J. Med. Chem.
44, 4230 (2001),
Abstract;
