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Retinoic acid, all trans

Retinoic acid receptor ligand
 
BML-GR100-0500 500 mg 63.00 USD
 
BML-GR100-5000 5 g 330.00 USD
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Retinoic acid is the active metabolite of vitamin A. It is a potent modulator of growth and differentiation exerting its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. All trans retinoic acid binds to RAR α, β and γ subtypes with Kd values of 0.2, 0.4 and 0.2 nM respectively. RARs function as ligand-dependent transcription factors. Retinoic Acid also promotes the differentiation of mouse embryonic stem cells into adipocytes, neurons and glia in vitro. It guides development of the posterior part of the embryo.

Product Specification

Formula:C20H28O2
 
MW:300.4
 
CAS:302-79-4
 
Purity:≥95%
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (25 mg/ml) or ethanol (10 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities: S. Chem, et al.; Nat. Commun. 7, 10309 (2016), Application(s): Cell culture, Abstract;
Retinoic Acid Modulates Interferon-γ Production by Hepatic Natural Killer T Cells via Phosphatase 2A and the Extracellular Signal-Regulated Kinase Pathway: H.K. Chang, et al.; J. Interferon Cytokine Res. 35, 200 (2015), Abstract; Full Text
Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors alpha, beta, and gamma. Retinoic acid receptor gamma binds all-trans-retinoic acid preferentially over 9-cis-retinoic acid: G. Allenby, et al.; J. Biol. Chem. 269, 16689 (1994), Abstract; Full Text
Multiplicity generates diversity in the retinoic acid signalling pathways: M. Leid, et al.; Trends Biochem. Sci. 17, 427 (1992), Abstract;
Retinoids and their receptors in differentiation, embryogenesis, and neoplasia: L.M. DeLuca, et al.; FASEB J. 5, 2924 (1991), Abstract; Full Text
Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud: C. Thaller & G. Eichele; Nature 345, 815 (1990), Abstract;

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