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N-Arachidonylglycine

FAAH inhibitor
 
BML-FA029-0005 5 mg 40.00 USD
 
BML-FA029-0025 25 mg 170.00 USD
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Replaces Prod. #: ALX-340-055

Endogenous anandamide-like compound. Lacks affinity for CB1 receptors (Ki>10µM), TRPV1 (EC50>10µM) and anandamide uptake (IC50>50µM), but inhibits fatty acid amide hydrolase (FAAH) (IC50=8.5µM-50µM, depending on cell type and species). Displays anti-inflammatory and analgesic activity. Identified as an insulin secretagogue in a primary β-cell-based functional assay. Represents a new class of "lipoamino acids".

Product Specification

Formula:C22H35NO3
 
MW:361.5
 
Source:Synthetic.
 
CAS:179113-91-8
 
Purity:≥98% (TLC)
 
Appearance:White waxy solid.
 
Solubility:Soluble in DMSO or 100% ethanol. 2mg/ml soluble in PBS (pH 7.2).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from air.
 
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Product Literature References

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor.: D. McHugh, et al.; BMC Neurosci. 11, 44 (2010), Abstract;
Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18: M. Kohno, et al.; BBRC 347, 827 (2006), Abstract;
A structure-activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase: M. Grazia Cascio, et al.; BBRC 314, 192 (2004), Abstract;
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain: S.M. Huang, et al.; J. Biol. Chem. 276, 42639 (2001), Abstract;
Oxidative metabolism of anandamide: S.H. Burstein, et al.; Prostaglandins Other Lipid Mediat. 61, 29 (2000), Abstract;
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor: T. Sheskin, et al.; J. Med. Chem. 40, 659 (1997), Abstract;

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