Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.
Product Details
| Alternative Name: | Compound C, Dorsomorphin |
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| Formula: | C24H25N5O |
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| MW: | 399.5 |
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| CAS: | 866405-64-3 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (3mg/ml, warm) |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Abstract;
Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system: U. Karunakaran, et al.; Redox Biol.
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Application(s): Treatment of rat INS-1 insulinoma cell line,
Abstract;
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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase: B. Zhou, et al.; Cell Rep.
37, 109785 (2021),
Abstract;
SIRT1-Dependent Upregulation of BDNF in Human MicrogliaChallenged with Aβ: An Early but Transient Response Rescuedby Melatonin: G.I. Caruso, et al.; Biomedicines
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Abstract;
Stereospecific inhibition of AMPK by (R)-crizotinib induced changes to the morphology and properties of cancer and cancer stem cell-like cells: T.H. Kim, et al.; Eur. J. Pharmacol.
911, 174525 (2021),
Abstract;
Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway: B.H. Chen, et al.; Sci. Rep.
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Abstract;
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SIRT1 Mediates Melatonin's Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence: S. Merlo, et al.; Biomolecules
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Abstract;
Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms: M. Panse, et al.; PLoS One
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Abstract;
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AMPK dependent protective effects of metformin on tumor necrosis factor-induced apoptotic liver injury: L. Cai, et al. ; Biochem. Biophys. Res. Commun.
465, 381 (2015),
Application(s): Cell culture,
Abstract;
Compound C inhibits in vitro angiogenesis and ameliorates thrombin-induced endothelial barrier failure: D. Gündüz, et al.; Eur. J. Pharmacol.
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Application(s): Cell culture ,
Abstract;
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism: P. B. Yu et al.; Nat. Chem. Biol.
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Abstract;
C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase: E. K. Kim et al.; J. Biol. Chem.
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Abstract;
Role of AMP-activated protein kinase in mechanism of metformin action: G. Zhou et al.; J. Clin. Invest.
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Abstract;
