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BML-275

AMPK inhibitor
 
BML-EI369-0005 5 mg 88.00 USD
 
BML-EI369-0025 25 mg 357.00 USD
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Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.

Product Specification

Alternative Name:Compound C, Dorsomorphin
 
Formula:C24H25N5O
 
MW:399.5
 
CAS:866405-64-3
 
Purity:≥98% (TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (3mg/ml, warm)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
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Product Literature References

AMPK dependent protective effects of metformin on tumor necrosis factor-induced apoptotic liver injury: L. Cai, et al. ; Biochem. Biophys. Res. Commun. 465, 381 (2015), Application(s): Cell culture, Abstract;
Compound C inhibits in vitro angiogenesis and ameliorates thrombin-induced endothelial barrier failure: D. Gündüz, et al.; Eur. J. Pharmacol. 768, 165 (2015), Application(s): Cell culture , Abstract;
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism: P. B. Yu et al.; Nat. Chem. Biol. 4, 33 (2008), Abstract;
C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase: E. K. Kim et al.; J. Biol. Chem. 279, 19970 (2004), Abstract;
Role of AMP-activated protein kinase in mechanism of metformin action: G. Zhou et al.; J. Clin. Invest. 108, 108 (2001), Abstract;

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