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KN-93

CaM kinase inhibitor
 
BML-EI268-0001 1 mg 165.00 USD
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Replaces Prod. #: ALX-430-023

KN-93 is a potent, selective and cell-permeable inhibitor of CaM kinase II (IC50=370 nM). Does not significantly inhibit PKA. Causes cell-cycle arrest in NIH 3T3 fibroblasts and HeLa cells. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.

Product Specification

Formula:C26H29ClN2O4S
 
MW:501
 
CAS:139298-40-1
 
Purity:≥95% (HPLC)
 
Appearance:white to off-white solid
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 2 years after receipt. Stock solutions are stale for up to 3 months when stored at -20°C.
 
Handling:Protect from light. Hygroscopic.
 
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Product Literature References

Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway: R. Zhang, et al.; J. Cell Physiol. 232, 2145 (2017), Abstract;
Calmodulin-dependent protein kinase II is required for G1/S progression in HeLa cells: G. Rasmussen & C. Rasmussen ; Biochem. Cell Biol. 73, 201 (1995), Abstract;
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R. M. Tombes; Cell Growth. Differ. 6, 1063 (1995), Abstract;
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya et al.; Biochem. Biophys. Res. Commun. 195, 608 (1993),
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki et al.; Biochem. Biophys. Res. Commun. 191, 255 (1993), Abstract;
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi et al.; Biochem. Biophys. Res. Commun. 181, 968 (1991), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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