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Capsaicin

TRPV1 agonist
 
BML-EI125-0200 200 mg 109.00 USD
 
BML-EI125-1000 1 g 420.00 USD
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Replaces Prod. #: ALX-550-066

Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. Exhibits neuroprotective effects in a model of transient global cerebral ischemia. Induces release of substance P from afferent nociceptive specific neurons. Constituent of cayenne pepper. Powerful excitant of peropheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets.

Product Specification

Alternative Name:8-Methyl-N-vanillyl-6-nonenamide
 
Formula:C18H27NO3
 
MW:305.4
 
Source:Isolated from Capsicum  fruit.
 
CAS:404-86-4
 
Purity:≥98% (TLC)
 
Appearance:White to pale yellow.
 
Solubility:Soluble in 100% ethanol, methanol or chloroform. Sparingly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain: W. Ma & R. Quirion; Expert Opin. Ther. Targets 11, 307 (2007), Abstract;
Forty years in capsaicin research for sensory pharmacology and physiology: J. Szolcsanyi; Neuropeptides 38, 377 (2004), Abstract;
Capsaicin sensitive-sensory nerves and blood pressure regulation: P. Vaishnava & D.H. Wang; Curr. Med. Chem. Cardiovasc. Hematol. Agents 1, 177 (2003), Abstract;
Peppers and pain. The promise of capsaicin: B.M. Fusco & M. Giacovazzo ; Drugs 53, 909 (1997), Abstract;
Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential: Y.J. Surth & S.S. Lee; Life. Sci. 56, 1845 (1995), Abstract;
Topical capsaicin. A review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy and osteoarthritis: C. Rains & H.M. Bryson ; Drugs Aging 7, 317 (1995), Abstract;
Capsaicin: identification, nomenclature, and pharmacotherapy: G.A. Cordell & O.E. Araujo et al.; Ann. Pharmacother. 27, 330 (1993), Abstract;
Sensory neuron-specific actions of capsaicin: mechanisms and applications: S. Bevan & J. Szolcsanyi ; Trends Pharmacol. Sci. 11, 330 (1990), Abstract;
Role of tachykinins in neurogenic inflammation: B. Pernow ; J. Immunol. 135, 812s (1985), Abstract;

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