Replaces Prod. #: ALX-430-002
SIN-1 is a metabolite of molsidomine which decomposes spontaneously in solution in the presence of oxygen, releasing NO and superoxide anion under physiological conditions. Since NO and superoxide react to form peroxynitrite, SIN-1 may actually produce peroxynitrite under physiological conditions. It is a potent vasodilator and inhibitor of platelet aggregation and produces significant protective effects in myocardial ischemia-reperfusion. The effects of SIN-1 are markedly attenuated by nitroglycerin-induced tolerance. Inhibits cysteine proteases.
Product Details
Alternative Name: | SIN-1, Linsidomine |
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Formula: | C6H10N4O2 . HCl |
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MW: | 206.6 |
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CAS: | 33876-97-0 |
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Purity: | ≥98% (HPLC) |
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Identity: | Determined by NMR. |
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Appearance: | White to off-white solid. |
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MeltingPoint: | 186-187°C |
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Solubility: | Soluble in water (25mg/ml), 100% ethanol or DMSO (>5mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Handling: | Use freshly prepared solutions. |
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Regulatory Status: | RUO - Research Use Only |
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