Online Purchasing Account You are logged on as Guest. Login Register a New Account Shopping cart (Empty)

Rp-cAMPS

PKA inhibitor



BML-CN135-0001	1 mg	172.00 USD
Do you need bulk/larger quantities?

Replaces Prod. #: ALX-480-012

Rp-cAMPS is a potent and specific competitive inhibitor of the activation of cAMP-dependent protein kinases by cAMP (IC₅₀=4.9 µM) . Its cell permeability and complete resistance to cyclic nucleotide phosphodiesterases make it a unique tool for studying cAMP-dependent signaling. Significantly more lipophilc as compared to cAMP and thus membrane permeable in many biological systems. This product is not sterile.

Product Details

Formula:	C₁₀H₁₁N₅O₅PS . C₆H₁₆N

MW:	446.5

Source:	Synthetic.

CAS:	151837-09-1

Purity:	≥98% (HPLC)

Appearance:	Clear film.

Solubility:	Soluble in water (25mg/ml), aqueous buffers, methanol, 100% ethanol or DMSO.

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Use/Stability:	Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Regulatory Status:	RUO - Research Use Only

Please mouse over

Product Literature References

Disruption of Mitochondrial-associated ER membranes by HIV-1 tat protein contributes to premature brain aging: S.P. Arjona, et al.; CNS Neurosci. Ther. 29, 365 (2023), Abstract;

Biased signaling initiated by agouti-related peptide through human melanocortin-3 and − 4 receptors: Z. Yang & Y.X. Tao; Biochim. Biophys. Acta 1862, 1485 (2016), Application(s): Cell culture, Abstract;

Proangiogenic Effect of TSH in Human Microvascular Endothelial Cells through Its Membrane Receptor: S. Balzan, et al.; J. Clin. Endocrinol. Metab. 97, 1763 (2012), Application(s): Inhibition of cAMP signaling in HMEC-1 and HMVEC cell culture, Abstract;

Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells: T. Bouschet et al.; J. Biol. Chem. 278, 4778 (2003), Abstract;

Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium: P. Schaap et al.; J. Biol. Chem. 268, 6323 (1993), Abstract;

Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases: L.Y. Wang et al.; Science 253, 1132 (1991), Abstract;

Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3’,5’-monophosphorothioates: E. Butt et al.; FEBS Lett. 263, 47 (1990), Abstract;

Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3’,5’-cyclic phosphorothioates: W.R.G. Dostmann et al.; J. Biol. Chem. 265, 10484 (1990), Abstract;

A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3’,5’-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase: J.D. Rothermel & L.J. Parker Bothelo; Biochem. J. 251, 757 (1988), Abstract;

cAMP analog antagonists of cAMP action: L.H. Botelho et al.; Methods Enzymol. 159, 159 (1988), Abstract;

Hydrolysis of cyclic nucleotides by a purified cGMP-stimulated phosphodiesterase: structural requirements for hydrolysis: T. Braumann et al.; Biochim. Biophys. Acta. 871, 199 (1986), Abstract;